Database : HANSEN Search on : ESTUDOS RETROSPECTIVOS [Subject descriptor] References found : 44 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 17556 Author: Gill, A. L; Bell, D. R; Gill, G. V; Wyatt, G. B; Beeching, N. J Title: Leprosy in Britain: 50 years experience in Liverpool ..- Source: s.l; s.n; Jun. 2005. 7 p. tab, graf. Abstract: BACKGROUND: Leprosy is a chronic infection that presents with varying dermal and neurological symptoms, and which can lead to extensive disability and morbidity, often with accompanying social stigma. AIM: To review the patients presenting to the Liverpool School of Tropical Medicine (LSTM) between 1946 and 2003, looking specifically at country of birth and of infection, details of clinical presentation, diagnosis, management and reactions. DESIGN: Retrospective record review. METHODS: We retrieved all available clinical records for patients seen between 1946 and 2003 (n = 50), consisting of letters, hospital and LSTM casenotes, and some radiographs and photographs. Any history of tuberculosis or diabetes was recorded. RESULTS: Most patients (64%) were born in the Indian subcontinent, and most were thought to have contracted the disease there (62%). Features at presentation included anaesthetic skin lesions in 19 (36%), hypopigmentation in 15 (30%), and peripheral nerve enlargement in 25 (50%). Diagnoses were made by a combination of clinical data and biopsy (60%), and slit skin smears were positive for acid-fast bacilli in 61% of multibacillary patients. Initial presentation was with a leprosy reaction in five cases (10%), and reactions were documented in 42% of all patients. Treatments were varied, progressing from traditional Eastern medicine to the WHO-approved multidrug therapy in use today, with prophylaxis for children and close contacts. DISCUSSION: Leprosy remains an important diagnosis to consider in patients with a history of work or travel in the tropics, and is a diagnosis with far-reaching medical, social and emotional consequences. (AU). Descriptors: Inglaterra/EP Índia/EH Hansenostáticos/TU Hanseníase/DI/DT/*EP Estudos Retrospectivos Dermatopatias Bacterianas/DI/EP/PA Limits: Adolescente Adulto Idoso Criança Feminino Humanos Masculino Meia-Idade Location: BR191.1; 09335/s

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Id: 17308 Author: Schmarz, Richard J; MacDonald, Mark Title: Assessment of results of opponensplasty ..- Source: s.l; s.n; 2003. 4 p. ilus, tab. Abstract: One hundred and fifty-six opponensplasties carried out on 115 patients at Anandaban Hospital between 1987 and 1997 were reviewed. In most cases a flexor digitalis superficialis opponensplasty was performed. The outcome was assessed by measuring the finger to which the thumb could obtain a pinch grip, the gap between the thumb and little metacarpophalangeal joints, and the satisfaction of the patient. The objective assessments demonstrated excellent or good results in 89%. Good or fair patient satisfaction was obtained in 93%. Early complications were seen in seven cases (4%). Objective measurements of outcome and patient satisfaction were not always in agreement, indicating that objective measures do not adequately assess the success of surgery from the patient's perspective. We thus conclude that subjective measurements of results are an important measure of success and should be included in the evaluation of surgical results. (AU). Descriptors: Dedos/IR/*SU Deformidades Adquiridas da Mão/*SU Força da Mão/*PH Hanseníase Tuberculóide/*SU Articulação Metacarpofalângica/SU Amplitude de Movimento Articular/PH Estudos Retrospectivos Transferência de Tendão/*MT Tendões Pararticulares Nepal Polegar/IR/*SU Limits: Adulto Contratura/*SU Feminino Seguimentos Humano Masculino Meia-Idade Location: BR191.1. 1140/s

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Id: 17282 Author: Singh, Navjeevan; Malik, Abha; Arora, Vinod K; Bhatia, Arati Title: Fine needle aspiration cytology of leprous neuritis ..- Source: s.l; s.n; 2003. 5 p. ilus, tab. Abstract: OBJECTIVE: To document the cytomorphologic features of leprous neuritis and their correlation with bacterial density. STUDY DESIGN: A partly retrospective, partly prospective study of the fine needle aspiration cytology of enlarged nerves in leprosy. Cytomorphologic features of nerve aspirates from 28 patients were studied. May-Grünwald-Geimsa and Ziehl-Neelsen staining methods were employed. RESULTS: Five cytomorphologic patterns were observed in smears of nerve aspirates in 19 group I patients with concurrent skin and nerve lesions: (1) inflammation composed of epithelioid cell granulomas (5), bacillary index (BI) = 0; (2) epithelioid cell granulomas with necrosis (5), BI = 0-1+; (3) acellular necrosis (5), BI = 0-4+; (4) macrophage granuloma (3), BI = 5-6+; and (5) granulation tissue (1), BI = 1+. In 9 group II patients with pure neuritic leprosy, 3 patterns were seen: (1) epithelioid cell granulomas (5), BI 0-6+; (2) epithelioid granulomas with necrosis (1), BI = 0; and (3) acellular necrosis (3), BI = 0-6+. CONCLUSION: The entire spectrum of leprosy is seen in nerve aspirates. Necrosis is often a prominent feature. Recognition of the range of cytomorphologic patterns and their correlation with BI contribute to accurate calibration of the disease in nerves, resulting in appropriate choice of treatment. (AU). Descriptors: Granuloma/MI/PA Hanseníase Tuberculóide/CO/*PA Mycobacterium leprae/IP/PY/PH Neurite/MI/*PA Nervos Periféricos/MI/*PA Estudos Prospectivos Estudos Retrospectivos Limits: Adolescente Adulto Criança Feminino Humano Masculino Meia-Idade Location: BR191.1; 09181/s

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Id: 15627 Author: Kaluarachchi, S. I; Fernandopulle, B. M. R; Gunawardane, B. P Title: Hepatic and haematological adverse reactions associated with the use of multidrug therapy in leprosy - a five year retrospective study ..- Source: s.l; s.n; 2001. 9 p. tab. Abstract: This study analyses retrospectively some of the risks associated with the use of WHO-multidrug therapy (MDT) in Sri Lanka. Case records of 3,333 new cases of leprosy attending the Central Leprosy Clinic in Colombo during 1991-1995, were analysed for adverse drug reactions involving the liver and blood. There were 81 reports of suspected hepatic or haematological adverse reactions associated with the use of MDT, of which 39 were classified as haemolytic anaemia, 25 as toxic hepatitis, 2 as methaemoglobinaemia and 15 as anaemia. Dapsone, was incriminated in the majority of adverse reactions (72 per cent). Adverse drug reactions were more common in female than male subjects (55 per cent vs 45 per cent; P < 0.5), but there was no significant differences between the age groups. Majority of adverse reactions was seen within the first three months of initiation of MDT. This study in no way undermines the benefits of MDT but highlights the risks and suggests measures to minimize these risks. (AU). Descriptors: ANEMIA/ind quim ANEMIA/epidemiol CLOFAZIMINA/ef adv DAPSONA/ef adv QUIMIOTERAPIA COMBINADA HEPATITE TOXICA/epidemiol HANSENOSTATICOS/ef adv HANSENOSTATICOS/uso terap HANSENIASE/quimioter ESTUDOS RETROSPECTIVOS RIFAMPINA/ef adv RIFAMPINA/uso terap METEMOGLOBINEMIA/ind quim METEMOGLOBINEMIA/epidemiol Limits: HUMANO MASCULINO FEMININO CRIANÇA ADULTO MEIA-IDADE ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 09163/s

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Id: 13943 Author: Murray, Clinton K; Joyce, M. Patricia; Longfield, Robert N Title: Short report: treatment failure in Hanse´n's disease ..- Source: s.l; s.n; 2003. 2 p. tab. Abstract: Areas of low endemicity of Hansen's disease, such as Texas, California, and Hawaii, exist due to immigration and rare autochthonous infections. Managing this disease in these areas of low endemicity is difficult, especially in observing for relapse. The accurate diagnosis of relapse is imperative so that appropriate therapy can be promptly reinstituted and unnecessary treatment can be avoided. To assess treatment failures in an area of low endemicity, we retrospectively evaluated 113 patients with Hansen's disease treated in southern Texas. Of 57 patients who completed therapy, 11 were later restarted on medications for this disease for presumed relapse. However, nine of the 11 were found not to have true relapses of Hansen's disease. The accurate diagnosis of relapse of this disease is essential not only in the individual patient but also for prospective treatment trials to establish best practices. (AU). Descriptors: CLOFAZIMINA/admin DAPSONA/admin QUIMIOTERAPIA COMBINADA HANSENIASE/quimioter HANSENIASE/epidemiol HANSENIASE/patol HANSENIASE/prev REGISTROS MEDICOS RECIDIVA ESTUDOS RETROSPECTIVOS RIFAMPINA/admin TEXAS/epidemiol FALHA DE TRATAMENTO RECUSA DO PACIENTE AO TRATAMENTO Limits: HUMANO MASCULINO FEMININO CRIANÇA ADULTO MEIA-IDADE IDOSO ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 09084/s

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Id: 13728 Author: DeRossi, Scott S; Hersh, Elliot V Title: Antibiotics and oral contraceptives ..- Source: s.l; s.n; 2002. 7 p. ilus, graf. Abstract: With the exception of rifampin-like drugs, there is a lack of scientific evidence supporting the ability of commonly prescribed antibiotics, including all those routinely employed in outpatient dentistry, to either reduce blood levels and/or the effectiveness of oral contraceptives. To date, all clinical trials studying the effects of concomitant antibiotic therapy (with the exception of rifampin and rifabutin) have failed to demonstrate an interaction. Like all drugs, oral contraceptives are not 100 per cent effective with the failure rate in the typical United States population reported to be as high as 3 per cent. It is thus possible that the case reports of unintended pregnancies during antibiotic therapy may simply represent the normal failure rate of these drugs. Considering that both drug classes are prescribed frequently to women of childbearing potential, one would expect a much higher rate of oral contraceptive failure in this group of patients if a true drug:drug interaction existed. On the other hand, if the interaction does exist but is a relatively rare event, occurring in, say, 1 in 5000 women, clinical studies such as those described in this article would not detect the interaction. The pharmacokinetic studies of simultaneous antibiotic and oral contraceptive ingestion, and the retrospective studies of pregnancy rates among oral contraceptive users exposed to antibiotics, all suffer from one potential common weakness, i.e., their relatively small sample size. Sample sizes in the pharmacokinetic trials ranged from 7 to 24 participants, whereas the largest retrospective study of pregnancy rates still evaluated less than 800 total contraceptive users. Still, the incidence of such a rare interaction would not differ from the accepted normal failure rate of oral contraceptive therapy. The medico-legal ramifications of what looks like at best a rare interaction remains somewhat "murky." On one hand, we have medico-legal experts advising the profession to exercise caution and warn all oral contraceptive users of a potential reduction in efficacy during antibiotic therapy. These opinions are not evidence-based and rely heavily on one or two legal proceedings that cannot even be substantiated. On the other hand, there is one recently published legal proceeding in which the outcome was in favor of the oral surgeon. There is clearly...(AU). Descriptors: VIES (EPIDEMIOLOGIA) DISPONIBILIDADE BIOLOGICA ANTIBIOTICOS/farmacocin ANTIBIOTICOS/uso terap ESTUDOS RETROSPECTIVOS ABSORCAO INTESTINAL/ef drogas RIFABUTINA/uso terap RIFAMPINA/uso terap ANTICONCEPCIONAIS ORAIS/antag ANTICONCEPCIONAIS ORAIS/farmacocin ANTICONCEPCIONAIS ORAIS/uso terap - INTERACOES DE MEDICAMENTOS  ENSAIOS CLINICOS  JURISPRUDÊNCIA  TAMANHO DA AMOSTRA Limits: HUMANO FEMININO GRAVIDEZ Electronic Medium: http://www.ilsl.br Location: BR191.1; 09018/s

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Id: 13655 Author: Kaluarachchi, S. I; Fernandopulle, B. M. R; Gunawardane, B. P Title: Hepatic and haematological adverse reactions associated with the use of multidrug therapy in leprosy - a five year retrospective study ..- Source: s.l; s.n; 2001. 9 p. tab. Abstract: This study analyses retrospectively some of the risks associated with the use of WHO-multidrug therapy (MDT) in Sri Lanka. Case records of 3,333 new cases of leprosy attending the Central Leprosy Clinic in Colombo during 1991-1995, were analysed for adverse drug reactions involving the liver and blood. There were 81 reports of suspected hepatic or haematological adverse reactions associated with the use of MDT, of which 39 were classified as haemolytic anaemia, 25 as toxic hepatitis, 2 as methaemoglobinaemia and 15 as anaemia. Dapsone, was incriminated in the majority of adverse reactions (72 per cent). Adverse drug reactions were more common in female than male subjects (55 per cent vs 45 per cent; P < 0.5), but there was no significant differences between the age groups. Majority of adverse reactions was seen within the first three months of initiation of MDT. This study in no way undermines the benefits of MDT but highlights the risks and suggests measures to minimize these risks. (AU). Descriptors: ANEMIA/ind quim ANEMIA/epidemiol CLOFAZIMINA/ef adv DAPSONA/ef adv QUIMIOTERAPIA COMBINADA HEPATITE TOXICA/epidemiol HANSENOSTATICOS/ef adv HANSENOSTATICOS/uso terap HANSENIASE/quimioter METEMOGLOBINEMIA/ind quim METEMOGLOBINEMIA/epidemiol ESTUDOS RETROSPECTIVOS RIFAMPINA/ef adv RIFAMPINA/uso terap Limits: HUMANO MASCULINO FEMININO CRIANÇA ADULTO ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 09123/s

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Id: 13641 Author: Goulart, Isabela Maria Bernades; Arbex, Guilherme Leonel; Carneiro, Marcus Hubaide; Rodrigues, Mariana Scalia; Gadia, Rafael Title: Efeitos adversos da poliquimioterapia em pacientes com hanseníase: um levantamento de cinco anos em um Centro de Saúde da Universidade Federal de Uberlândia Adverse effects of multidrug therapy in leprosy patients: a five-year survey at a Health Center of the Federal University of Uberlandia- Source: s.l; s.n; set.-out. 2002. 8 p. tab. Abstract: The introduction of multidrug therapy (WHO/MDT)-composed by the drugs dapsone, clofazimine and rifampicin has enabled the cure of Hansen's disease, however, the adverse effects of these drugs were not given priority by the health team. Aiming to determine MDT's adverse effects' magnitude and relate them to the non-adhesion of patients to the treatment, a study of 187 charts of patients treated with MDT from January of 1995 to May 2000, was carried out at a Health Center of the Federal University of Uberlandia. Side effects were recorded in 71 patients' charts. Among the 113 side effects found, 80 (70.7 per cent) were related to dapsone, 7 (6.2 per cent) were caused by rifampicin and 26 (20.5 per cent) were attributed to clofazimine. These effects induced 28 (14.9 per cent), patients to change the therapeutic scheme, representing 39.4 per cent from the 71 patients with adverse effects. Throughout this study, the importance is discussed of considering MDT's adverse effects when training the health team to heighten the patient's adhesion to the treatment and thereby collaborating to eliminate Hansen's disease as a public health problem. (AU). Descriptors: CLOFAZIMINA/admin CLOFAZIMINA/ef adv DAPSONA/admin DAPSONA/ef adv QUIMIOTERAPIA COMBINADA HANSENOSTATICOS/admin HANSENOSTATICOS/ef adv HANSENIASE/quimioter COOPERACAO DO PACIENTE/estatíst DESISTÊNCIA DO PACIENTE/estatíst ESTUDOS RETROSPECTIVOS RIFAMPINA/admin RIFAMPINA/ef adv Limits: PRÉ-ESCOLAR CRIANÇA ADOLESCENCIA ADULTO RESUMO EM INGLES FEMININO HUMANO LACTENTE RECEM-NASCIDO MASCULINO MEIA-IDADE Location: BR191.1; 09017/s

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Id: 12273 Author: Nakayama, Edson Eiji; Ura, Somei; Fleury, Raul Negrão; Soares, Vitor Title: Renal lesions in leprosy: a retrospective study of 199 autopsies ..- Source: s.l; s.n; July 2001. 5 p. ilus, tab, graf. Descriptors: AUTOPSIA RIM NEFROPATIAS NEFROPATIAS HANSENIASE HANSENIASE ESTUDOS RETROSPECTIVOS ANALISE DE SOBREVIVENCIA Location: BR191.1; 08625/s

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Id: 12259 Author: Lockwood, D. N. J; Reid, A. J. C Title: The diagnosis of leprosy is delayed in the United Kingdom ..- Source: s.l; s.n; 2001. 6 p. ilus, tab. Descriptors: IDADE DE INICIO BIOPSIA ERROS DE DIAGNOSTICO HANSENIASE EXAME FISICO REFERENCIA E CONSULTA ESTUDOS RETROSPECTIVOS VIAGEM Location: BR191.1; 08986/s

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Id: 12257 Author: Diniz, Lúcia M; Zandonade, Eliane; Dietze, Reynaldo; Pereira, Fausto E. L; Ribeiro-Rodrigues, Rodrigo Title: Short report: do intestinal nematodes increase the risk for multibacillary leprosy? ..- Source: s.l; s.n; 2001. 3 p. tab. Descriptors: ADOLESCENCIA BRASIL PRÉ-ESCOLAR ENTEROPATIAS PARASITARIAS ENTEROPATIAS PARASITARIAS HANSENIASE HANSENIASE HANSENIASE REGISTROS MÉDICOS MYCOBACTERIUM LEPRAE INFECÇOES POR NEMATOIDES INFECÇOES POR NEMATOIDES ESTUDOS RETROSPECTIVOS INDICE DE GRAVIDADE DE DOENÇA Location: BR191.1; 08665/s

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Id: 12239 Author: Keita, S; Tiendrebeogo, A; Konare, H; Cisse, B.-S; Faye, O Title: Nouveaux cas de lèpre à L'Institut Marchoux (Bamako, Mali): Etude comparative 1988-1997 New cases of leprosy at the Marchoux Institute: a comparative study 1988-1997- Source: s.l; s.n; 2001. 3 p. tab. Descriptors: CRIANÇA ESTUDOS TRANSVERSAIS HANSENIASE MALI ESTUDOS RETROSPECTIVOS ESTUDOS PROSPECTIVOS Limits: ESTUDO COMPARATIVO Location: BR191.1; 08641/s

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Id: 12229 Author: Santos, Adalberto Rezende; Balassiano, Vivian; Oliveira, Maria Leide W; Pereira, Marcia Aparecida da Silva; Santos, Patricia Barros; Degrave, Wim Maurits; Suffys, Philip Noel Title: Detection of mycobacterium leprae DNA by polymerase chain reaction in the blood of individuals, eight years after completion of anti-leprosy therapy ..- Source: Rio de Janeiro; s.n; Nov. 2001. 5 p. tab. Descriptors: DNA BACTERIANO LEPROSTATICOS HANSENIASE ESQUEMA DE MEDICAÇAO MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE REAÇAO EM CADEIA POR POLIMERASE ESTUDOS RETROSPECTIVOS Limits: ESTUDO COMPARATIVO Location: BR191.1; 08712/s; BR191.1; 08725/s

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Id: 12124 Author: Flageul, B Title: Enquête épidémiologique sur la lèpre en France métropolitaine de 1995 à 1998 ..- Source: s.l; s.n; 2001. 4 p. graf. Descriptors: COLETA DE DADOS FRANÇA HANSENIASE QUESTIONARIOS ESTUDOS RETROSPECTIVOS SAUDE URBANA Location: BR191.1; 08700/s

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Id: 12121 Author: Malik, R; Martin, P; Wigney, D; Swan, D; Sattler, P. S; Cibilic, D; Allen, J; Mitchell, D. H; Chene, S. C. A; Hughes, M. S; Love, D. N Title: Treatment of canine leproid granuloma syndrome: preliminary findings in seven dogs ..- Source: s.l; s.n; jan. 2001. 7 p. ilus, tab. Descriptors: CLARITROMICINA DOENÇAS DO CAO DOENÇAS DO CAO CAES ESQUEMA DE MEDICAÇAO QUIMIOTERAPIA COMBINADA LEPROSTATICOS HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA NEW SOUTH WALES ESTUDOS RETROSPECTIVOS RIFAMPINA Limits: RELATO DE CASO ANIMAL Location: BR191.1; 08697/s

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Id: 11715 Author: Malik, R; Martin, P; Wigney, D; Swan, D; Sattler, P. S; Cibilic, D; Allen, J; Mitchell, D. H; Chen, S. C. A; Hughes, M. S; Love, D. N Title: Treatment of canine leproid granuloma syndrome: preliminary findings in seven dogs ..- Source: s.l; s.n; 2001. 7 p. ilus, tab. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA CLARITROMICINA DOENÇAS DO CAO DOENÇAS DO CAO CAES ESQUEMA DE MEDICAÇAO QUIMIOTERAPIA COMBINADA LEPROSTATICOS ESTUDOS PROSPECTIVOS ESTUDOS RETROSPECTIVOS RIFAMPINA SINDROME Limits: RELATO DE CASO ANIMAL CAES FEMININO MASCULINO Location: BR191.1; 07358/s

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Id: 11694 Author: Suite, M Title: Relapse rates following leprosy multidrug therapy ..- Source: s.l; s.n; 2000. 2 p. . Descriptors: HANSENIASE HANSENIASE QUIMIOTERAPIA COMBINADA LEPROSTATICOS LEPROSTATICOS RECIDIVA ESTUDOS RETROSPECTIVOS TRINIDAD E TOBAGO Location: BR191.1; 08486/s; 08488/s

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Id: 11652 Author: Nakayame, Edson Eiji; Ura, Somei; Fleury, Raul Negrão; Soares, Vitor Title: Renal lesions in leprosy: a retrspective study of 199 autopsies ..- Source: s.l; s.n; 2001. 5 p. ilus, tab, graf. Descriptors: HANSENIASE HANSENIASE AUTOPSIA RIM ESTUDOS RETROSPECTIVOS AMILOIDOSE Limits: FEMININO HUMANO MASCULINO MEIA-IDADE IDOSO Location: BR191.1; 08460/s

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Id: 11466 Author: Cho, Sang-Nae; Cellona, Roland V; Villahermosa, Laarni G; Fajardo Junior, Tranquilino T; Balagon, M. Victoria F; Abalos, Rodolfo M; Tan, Esterlina V; Walsh, Gerald P; Kim, Joo-Deuk; Brennan, Patrick J Title: Detection of phenolic glycolipid I of mycobacterium leprae in sera fron leprosy patients before and after start of multidrug therapy ..- Source: s.l; s.n; 2001. 5 p. ilus, tab, graf. Descriptors: ANTIGENOS DE BACTÉRIAS ELISA GLICOLIPIDIOS LEPROSTATICOS HANSENIASE HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE ESTUDOS RETROSPECTIVOS Location: BR191.1; 08345/s

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Id: 11465 Author: Chen, Xiang-Sheng; Li, Wen-Zhong; Jiang, Cheng; Ye, Gan-Yun Title: Leprosy in children: a retrospective study in China, 1986-1997 ..- Source: s.l; s.n; 2000. 5 p. tab. Descriptors: ADOLESCENCIA CRIANÇA FATORES ETARIOS PRÉ-ESCOLAR CHINA LACTENTE PREVALENCIA TRIAGEM DE MASSA ESTUDOS RETROSPECTIVOS HANSENIASE HANSENIASE Location: BR191.1; 08344/s

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